Physician's CHOICE Probiotics 60 Billion CFU - 10 Unique Strains + Organic Prebiotic, Crafted for Overall Digestive Health, Gut Health, Occasional Constipation, Gas & Bloating - 2 Month Supply

Product Information

While we think of our digestive system mainly for its role in processing food and getting us the nutrients that we need, it is also one of the most active components of our immune system. Data suggest that probiotic bacteria directly and indirectly enhance a protective immune response.

The selection was performed with the reference management program EndNote X9 (Clarivate Analytics, Philadelphia, PA, USA). After automatic and manual duplicate removal, two independent investigators manually selected the articles stepwise, first by title and abstract and subsequently by full-text contents adhering to the predefined eligibility criteria. Cohen’s kappa coefficient was calculated at each selection step to quantify the agreement between assessors. Disagreements were solved by consensus. Data collection Gilbert JA, Lynch SV. Community ecology as a framework for human microbiome research. Nat Med. 2019;25:884–9. Our formula contains no genetically modified or pathogenic microorganisms. Each ingredient used to culture the microbes is 100% natural. By controlling our own manufacturing and maintaining rigorous quality control standards, we’re able to provide you with consistent, high-end probiotics every time! Long shelf-life Our acid-resistant vegetable capsules delay the release of probiotics to protect them from the harsh acidity of your stomach. This ensures maximum survivability and allows the friendly microbes to release deeper in your digestive tract. Maximum potency Madden JAJ, Plummer SF, Tang J, Garaiova I, Plummer NT, Herbison M, et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebo-controlled pilot study. Int Immunopharmacol. 2005;5:1091–7.

Guarner F, Sanders ME, Szajewska H, Cohen H, Eliakim R, Herrera C, et al. WGO Practice Guideline. Probiotics and Prebiotics. World Gastroenterol Organ Glob Guidel. 2023:1–53. Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, et al. Blautia—a new functional genus with potential probiotic properties? Gut Microbes. 2021;13:1–21. Inthout J, Ioannidis JP, Borm GF. The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method. BMC Med Res Methodol. 2014;14:1–12. Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med. 2003;22:2693–710.

Dale, H. F., et al. (2019). Probiotics in irritable bowel syndrome: An up-to-date systematic review.PRO biotika jsou živé mikroorganismy s výhodnými účinky vůči zdraví. Často se označují za "přítelské" nebo "dobré" bakterie, které podporují imunitní systém, střeva a celkové zdraví. Existují přirozeně v trávícím traktu a pomáhají chránit proti škodlivým bakteriím a plísním. Roswell M, Dushoff J, Winfree R. A conceptual guide to measuring species diversity. Oikos. 2021;130:321–38. Chen L, Xu W, He J, Lee A, Si J, Chen S. The impact of Helicobacter pylori infection, eradication therapy, and probiotic supplementation on gut microenvironment homeostasis: an open-label, prospective clinical trial. J Gastroenterol Hepatol. 2018;33:54–221. Forssten S, Evans M, Wilson D, Ouwehand AC. Influence of a probiotic mixture on antibiotic induced microbiota disturbances. World J Gastroenterol. 2014;20:11878–85.

Shi J, Luo D, Weng H, Zeng XT, Lin L, Chu H, et al. Optimally estimating the sample standard deviation from the five-number summary. Res Synth Methods. 2020;11:641–54. Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary Lance GN, Williams WT. Computer programs for hierarchical polythetic classification (“similarity analyses”). Comput J. 1966;9:60–4.At phylum level, a decreasing trend in the proportion of Firmicutes and Bacteroidetes with a higher relative abundance of Proteobacteria was observed after antibiotic therapy in both groups, regardless of probiotic supplementation. There was also a reduction in the Bacteroidetes:Firmicutes (B:F) ratio at the cessation of treatments. This was confirmed by several studies; however, in the study of Oh et al., the reduction was significantly greater in the control group [ 43, 52, 56]. Importantly, these changes in phyla abundances disappeared at day 56 in the studies of Chen et al. and Tang et al. [ 52, 64]. Kriss M, Hazleton KZ, Nusbacher NM, Martin CG, Lozupone CA. Low diversity gut microbiota dysbiosis: drivers, functional implications and recovery. Curr Opin Microbiol. 2018;44:34–40.